Founded in 1954 by a husband-and-wife duo, this ceramics studio carries on a powerful artistic legacy.

The birthplace and original home of the legendary American playwright.

Since 1939, this no-frills spot has been turning out perfectly seasoned renditions of a Delta staple.

A steeple in the shape of a golden hand pointing straight up commemorates Zebulun Butler, the first full-time pastor of this Mississippi church.

The final resting place of an esteemed bear hunter and formerly enslaved man who led Theodore Roosevelt on a hunting trip that inspired the creation of the teddy bear.

An enormous, interactive museum with star-studded exhibits is surprisingly found deep in the Mississippi Delta.

This house designed by Frank Lloyd Wright and Louis Sullivan was destroyed twice and reconstructed to near original condition.

A downtown filled with nearly deserted historic buildings was revived as a pastel paradise.

One of the best-preserved Native American mounds remaining in the southern United States.

This two-room shotgun shack in Tupelo is the birthplace of a King.

A Muppet museum in small-town Mississippi honors the roots of Jim Henson's most beloved creation.

Giant novelty guitars now mark the spot where Robert Johnson is said to have sold his soul to the devil.

An eerie and beautiful group of columns mark the site of a grand mansion lost to time and fire.

A decaying building marks the site associated with Emmett Till's brutal 1955 murder, which helped sparking the civil rights movement.

This architectural triumph is the only Frank Lloyd Wright house in Alabama.

This 1,500-acre development hopes to be the Central Park of the South.

The simple gravesite of a Romany clan leader is dotted with offerings, including cans of her favorite drink, Crush orange soda.

The first space rock known to have struck a human.

Live long and prosper in Tennessee.

This defunct, fortress-like prison has been the setting for several movies.

After the oysters have been shucked, and the restaurant's been shuttered, the terrazzo sidewalk from the 1940s is all that remains.

By day this New Orleans square is for pedestrians, but by night it is a kingdom of kittens.

The restaurant keeps a hidden séance room on the second floor and reserves a table for the spirit of the former owner each night.

A museum and shop on Bourbon Street located in the French Quarter.