Richard Luke Concanen never set foot on American soil.

The sacristy of this church contains remains and relics of members of the Aragonese royal family.

Locals pay their respects at a shrine to soccer player Diego Maradona—which claims to contain a real lock of his hair.

An unusual "skull with ears" sits in the crypt of this small church tucked away at the end of a narrow alley.

Every day is like Christmas on this street where the traditional Neapolitan nativity scene comes to life.

San Gennaro, the patron saint of Naples, greets pedestrians between these narrow city streets.

This whimsical fountain depicts a winged siren shooting water out of her nipples into the fires of Mount Vesuvius.

This ancient market is often referred to as the oldest shopping mall in the world.

This medieval church in Rome was almost destroyed following a terrorist attack in 1993.

This ancient Roman arch misled treasure hunters for centuries.

The yawning maw of this pagan visage is said to bite off the hands of liars.

The skull of the patron saint of lovers lies in the Basilica di Santa Maria in Cosmedin—maybe.

This curious, round temple is the oldest still-standing marble building in Rome.

This small, ancient Roman temple was once a church dedicated to the patron saint of penitents.

A rare example of a medieval house in Rome adorned with a melancholic inscription.

This small church was constructed over the ruins of three temples dating to the Roman Republic.

The only remaining arch of the oldest stone bridge in Rome stands in the middle of the Tiber.

This is the oldest Roman-made bridge in the city still existing in its original state.

In Rome’s Jewish ghetto, a 200-year-old bakery still makes the neighborhood’s historic sweets.

A 15th-century monumental Latin inscription on this house celebrates Lorenzo Manilio's love for Rome.

St. Francesca Romana, patron saint of drivers, resides in the church she founded.

An ancient Roman temple first dedicated to an emperor's wife is now a church.

A mysterious chasm in the heart of the ancient Roman Forum, the Lacus Curtius was once believed to be a gateway to hell.

This ancient Roman prison is decorated with an upside-down cross not as blasphemy but as saintly tribute.