The famous sculptor left his mark on this Italian wall in an internationally protected example of street art.

Over 50 exquisite hand-painted Renaissance maps decorate a Medici storage room.

Drink wine handed out through a window as part of an age-old tradition.

The largest and most famous wax anatomical collection anywhere in the world.

A large grotto built in the 16th century amidst Florence's famous Boboli gardens.

The oldest operating pharmacy in the world features 800-year-old recipes.

The middle finger of modernity.

This ancient market is often referred to as the oldest shopping mall in the world.

A mysterious chasm in the heart of the ancient Roman Forum, the Lacus Curtius was once believed to be a gateway to hell.

This ancient Roman prison is decorated with an upside-down cross not as blasphemy but as saintly tribute.

More sculpture than building, this architecturally significant temple was built on the spot of Saint Peter's crucifixion.

A magnificent waterfall is also home to the remains of a Roman hydraulic engineering system.

This large, circular tomb is the final resting place of the first emperor of Rome.

One of the most important yet well-hidden museums dedicated to the history of medicine.

A forgotten "city of water" underneath the famous Trevi district.

This ritzy Italian market is built around a statue of an unforgiven heretic who was burned for his belief in an endless universe.

In Rome’s Jewish ghetto, a 200-year-old bakery still makes the neighborhood’s historic sweets.

This beautiful park on the outskirts of Rome protects the ruins of two colossal ancient aqueducts.

The engineering wonder and pleasure dome of a much-maligned emperor still holds undiscovered secrets.

The final resting place of the poets Shelley and Keats.

2300-year-old Roman road connecting the empire.

The skull of the patron saint of lovers lies in the Basilica di Santa Maria in Cosmedin—maybe.

The only "Egyptian" pyramid in Europe and the legendary tomb of Remus.

An alchemist's “magic door” stands in the middle of a Roman park.