Colorful, cheeky signs spill out of legendary New Orleans folk artist Dr. Bob's Bywater studio warning you to "Be Nice—Or Leave."

This New Orleans boutique and nursery specializes in rare flora, with a focus on carnivorous plants.

The neighborhood surrounding the memorial was the epicenter of the AIDS epidemic in Louisiana.

This symbolic piece of New Orleans architecture is also home to a few ghastly stories.

Inside this art and oddity-filled shop, a small room filled with secrets.

This church on a Tohono O'Odham reservation has stood since 1797.

Run by members of the Tohono O'odham Nation, this community farm nurtures traditional desert cultivars.

This tucked-away cemetery is the final resting place of a prospector who uncovered one of the largest gold mines in Arizona.

Opinions differ as to whether this Arizona tree was actually used as a Wild West jail, but that hasn't stopped the town from capitalizing on it.

After a short-lived attempt to bring America in line with the rest of the world, this road was left in metric.

This iconic 1958 tower welcomes air travelers to Tucson with neon-lit letters and architectural style.

This sculpture may be the only known depiction of a man who helped finance the American Revolution and inadvertently created the dollar sign.

World's largest precision optical instrument used to detect Einstein's elusive gravity waves.

One of the longest water bridges in the world was built over a supposedly haunted swamp in Louisiana.

Experience a charming 1930s version of "infotainment."

An innovative attempt to break a siege in the American Civil War still scars the earth today.

A home built with marble tombstones from the graves of 2,200 Union soldiers buried in a Virginia cemetery.

The airport was once a Civil War battleground, and the earthwork defenses can still be seen today.

Home to the world's largest quilt collection dating from the 1600s through today.

This 19th-century benevolent society and jazz hall was rescued from abandonment to again host live music.

A 200-year-old live oak on the banks of Lake Pontchartrain.

Once defending the city of New Orleans from invasion by sea, this fort faces an uncertain future.

This strange, small castle on the bayou has withstood the test of time and weather.

The crumbling remains of a 19th century fortess.