Drink wine handed out through a window as part of an age-old tradition.

The oldest operating pharmacy in the world features 800-year-old recipes.

Plaques on its facade commemorate the Tiber's most destructive deluges.

This statue is the only female representation of Rome's "talking statues."

The remains of this 2nd-century Roman temple are incorporated into a modern building.

An ancient Roman temple first dedicated to an emperor's wife is now a church.

This ancient market is often referred to as the oldest shopping mall in the world.

This subterranean shrine beneath a bike rental store celebrates the iconic Italian scooter.

A detailed pachyderm supports Rome's smallest Egyptian obelisk.

The spot where the fascist dictator made some of his most famous speeches including declaring war on Britain and France.

Installed in an act of one-upsmanship, the annual sundial in this church is also a symbolic victory for the Gregorian calendar.

This former Roman Catholic Church still contains the embalmed hearts and organs of 22 popes.

This ritzy Italian market is built around a statue of an unforgiven heretic who was burned for his belief in an endless universe.

Hundreds of lucky felines haunt the ruins where Caesar was murdered.

Once decrepit and slated for demolition, now one of the longest pedestrian bridges in the world.

This historic train station has been converted to a locomotive themed hotel.

The mysterious wonder of an underground waterfall is illuminated by multicolored lights.

One of Cincinnati's greatest fighters once trained at a now defunct gym in this Over-The-Rhine neighborhood.

A hot dog stand where the heads are just as hot as the dogs.

A building so large that it has its own weather.

The unique collection includes bronze cast handprints of some of America's most famous astronauts.

This sprawling bookstore spans four floors and has more than a million books in stock.

A little piece of Paris in the sultry south of the U.S.

You can walk through the first Boeing Air Force One, which famously carried JFK's casket from Dallas back to D.C.