This old abandoned sign flickers to announce a motel that isn't even there.

A prison-like structure guards the remains of a notorious Old West outlaw.

A giant "X" symbolizes the blood spilled from the brutal Juárez drug wars.

This old ruin once served as a post office, a train station, a restaurant, and a bridge to the Atomic Age.

Once a dining hall for boarding school students, this lodge was a popular haunt for nuclear physicists working on the Manhattan Project.

Owned by Native American women, this brewery is a celebration of indigenous culture in the American Southwest.

In 1967, murder and mayhem disrupted the tranquility along this quiet stretch of Old Route 66.

For those going through a life transition, a place to leave behind a piece of your former self.

This sanguine boulevard was named after a deadly cowboy bar fight.

A motel dedicated to Southwestern nostalgia.

This little blue house pokes out over the campus of UC San Diego, seven stories high.

Instead of faces, these sculptures have barcodes—statements on societal dehumanization.

The so-called "Bridge of Thighs" in Palm Springs allows nudists to discreetly cross the road.

This giant spider sculpture made from the iconic car is one giant visual pun.

This outdoor observatory offers stellar views and a scale model of our solar system.

While exploring the desert, you can stop by the home of a fictional heretic from a parallel universe.

A fake town founded by Western movie stars is now becoming a hip desert community.

Megachurch turned Catholic church comprised of 10,000 glass panes.

This massive statue of John Muir on the side of a California highway was carved from a redwood tree.

The interior of the Overlook Hotel in "The Shining" was based on this Yosemite original.

A vaudeville performer mounted this hollowed-out redwood log onto the chassis of a truck, and toured the country spreading a message of conservation.

One of the most scenic stretches of road in America winds between some of the country's oldest trees.

Commonly referred to as the most photographed Victorian home in the United States.

This 19th-century museum inside of a lighthouse is only accessible during low tide.