The oldest operating apothecary in the US has treated everyone from Thomas Edison to Mark Twain.

Jimi Hendrix's legendary recording studio in Greenwich Village.

The oldest living tree in Manhattan comes shrouded in sinister legend.

A colossal watermelon slice celebrating Muscatine’s sweet agricultural heritage.

Nebraska’s longest-running summer theater is a musical tribute to cowboy culture.

This old-school soda shop is the home of the Tin Roof Sundae, a concoction dripping in chocolate, marshmallow, and peanuts.

One of the smallest towns in the United States.

Miraculous tree that seems to sprout out of solid rock.

The high point on the 16th president's eponymous roadway is marked by a massive version of his head.

The largest wildlife crossing in Utah allows local fauna to safely traverse the six-lane Interstate 80 at Parleys Canyon.

The location along the shores of the Great Salt Lake of what was once called, "The Coney Island of the West", now sits barren due to arson and time.

The self-made house sculpture of an outsider artist who named himself "Chief Rolling Thunder."

One of the most scenic stretches of road in America winds between some of the country's oldest trees.

A vaudeville performer mounted this hollowed-out redwood log onto the chassis of a truck, and toured the country spreading a message of conservation.

Two mammoth statues inspired by equally tall tales lure tourists to this roadside attraction.

This massive redwood tree has a hole in the base big enough to drive through.

A trash dump made beautiful by nature's power.

The unique waterfall in Iceland's south features a backdrop of geometric black lava columns.

A giant fiberglass Muffler Man found new life as a rodeo guardian.

Naturally carbonated water fills the mineral baths at this 19th-century California resort.

On the side of Highway 50 East, between Carson City and Dayton, Nevada, sits a giant metal spider made from a vintage Volkswagen Beetle.

This Old West eatery along America's Loneliest Road was originally a stop on the Pony Express.

A tree bears footwear on the loneliest road in America.

Officially named the "Loneliest Road in America," this barren stretch of Nevada road offers almost nothing but sky and open fields.